Doudna, J.A., Sternberg, S.H. A Crack in Creation: Gene editing and the unthinkable power to control evolution. New York: Houghton Mifflin Harcourt, 2017. Available now on Amazon.


Peer Reviewed Articles

Chen, J.S., Dagdas, Y.S., Kleinstiver, B.P., Welch, M.M., Harrington, L.B., Sternberg, S.H., Joung, J.K., Yildiz, A., Doudna, J.A. “Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.” bioRxiv and in review (2017). Link

Dagdas, Y.*, Chen, J.S.*, Sternberg, S.H., Doudna, J.A., Yildiz, A. “A conformational checkpoint between DNA binding and cleavage by CRISPR–Cas9.” Science Advances 3 (2017): eaao0027. Link

Jackson, R.N., van Erp, P.B., Sternberg, S.H., Wiedenheft, B. “Conformational regulation of CRISPR-associated nucleases.” Curr Opin Microbiol 21 (2017): 110-119. Link

Boyle, E.A.*, Andreasson, J.O.L.*, Chircus, L.M.*, Sternberg, S.H., Wu, M.J., Guegler, C.K., Doudna, J.A., Greenleaf, W.J. “High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding.” PNAS 114 (2017): 5461-5466. Link

Singh, D., Sternberg, S.H., Fei, J., Doudna, J.A., Ha, T. "Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9." Nat Comm 7, 12778 (2016). Link

Sternberg, S.H.*, Richter, H.*, Charpentier, E., Qimron, U. "Adaptation in CRISPR-Cas systems." Mol Cell 61, 797 (2016). Link

Sternberg, S.H., LaFrance, B., Kaplan, M., Doudna, J.A. "Conformational control of DNA target cleavage by CRISPR-Cas9." Nature 527, 110 (2015). Link

Redding, S., Sternberg, S.H., Marshall, M., Gibb, B., Bhat, P., Guegler, C.K., Wiedenheft, B., Doudna, J.A., Greene, E.C. "Surveillance and processing of foreign DNA by the Escherichia coli CRISPR-Cas system." Cell 163, 854 (2015). Link

Sternberg, S.H., Doudna, J.A. "Expanding the biologist’s toolkit with CRISPR-Cas9." Mol Cell 58,568 (2015). Link

Baltimore, D., Berg, P., Botchan, M., Carroll, D., Charo, R.A., Church, G., Corn, J.E., Daley, G.Q., Doudna, J.A., Fenner, M., Greely, H.T., Martin, G.S., Penhoet, E., Puck, J., Sternberg, S.H., Weissman, J.S., Yamamoto, K.R. "A prudent path forward for genomic engineering and germline gene modification." Science 348, 36 (2015). Link

Wright, A.V.*, Sternberg, S.H.*, Taylor, D.W., Staahl, B.T., Bardales, J.A., Kornfeld, J.E., Doudna, J.A. "Rational design of a split-Cas9 enzyme complex." PNAS 112, 2984 (2015). Link

O’Connell, M.R., Oakes, B.L., Sternberg, S.H., East-Seletsky, A., Kaplan, M., Doudna, J.A. "Programmable RNA recognition and cleavage by CRISPR/Cas9." Nature 516, 263 (2014). Link

Hochstrasser, M.L.*, Taylor, D.W.*, Bhat, P., Guegler, C.K., Sternberg, S.H., Nogales, E., Doudna, J.A. "CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference." PNAS 111, 6618 (2014). Link

Jinek, M.*, Jiang, F.*, Taylor, D.W*., Sternberg, S.H.*, Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M., Iavarone, A.T., Charpentier, E., Nogales, E., Doudna, J.A. "Structures of Cas9 endonucleases reveal RNA-mediated conformational activation." Science 343, 1247997 (2014). Link

Sternberg, S.H.*, Redding, S.*, Jinek, M., Greene, E.C., Doudna, J.A. "DNA interrogation by the CRISPR RNA-guided endonuclease Cas9." Nature 507, 62 (2014). Link

Haurwitz, R.E., Sternberg, S.H., Doudna, J.A. "Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA." EMBO J 31, 2824 (2012). Link

Sternberg, S.H., Haurwitz, R.E., Doudna, J.A. "Mechanism of substrate selection by a highly specific CRISPR endoribonuclease." RNA 18, 661 (2012). Link

Wiedenheft, B., Sternberg, S.H., Doudna, J.A. "RNA-guided genetic silencing systems in bacteria and archaea." Nature 482, 331 (2012). Link

Chakravarthy, S., Sternberg, S.H., Kellenberger, C.A., Doudna, J.A. "Substrate-specific kinetics of Dicer-catalyzed RNA processing." J Mol Biol 404, 392 (2010). Link

Fei, J., Wang, J., Sternberg, S.H., MacDougall, D.D., Elvekrog, M.M., Pulukkunat, D.K., Englander, M.T., Gonzalez, R.L. "A highly purified, fluorescently labeled in vitro translation system for single-molecule studies of protein synthesis." Meth Enzymol 472, 221 (2010). Link

Sternberg, S.H., Fei, J., Prywes, N., McGrath, K.A., Gonzalez, R.L. "Translation factors direct intrinsic ribosome dynamics during translation termination and ribosome recycling." Nat Struct Mol Biol 16, 861 (2009). Link

*These authors contributed equally.


Non-Peer Reviewed Articles

Sternberg, S.H. "Risky Business: A researcher’s death spurs an overhaul of safety at the UCs." The Berkeley Science Review, Spring 2013. Link

Sternberg, S.H. "Germ Warfare: Bacteria and viruses adapt for battle." The Berkeley Science Review, Fall 2012. Link